Having made his acting debut in 1992 with Yash Chopra's Parampara, Khan had his first success with the 1994 films Main Khiladi Tu Anari and Yeh Dillagi. After going through several years of decline throughout the 1990s, he rose into prominence with his performance in Farhan Akhtar's Dil Chahta Hai (2001), which marked his professional turning point. His work in Kal Ho Naa Ho (2003) won him the Filmfare Award for Best Supporting Actor, and he was awarded the National Film Award for Best Actor for his performance in Hum Tum (2004).
Khan subsequently had further mainstream success with films like Salaam Namaste (2005) and Race (2008) and starred in critically acclaimed projects such as Parineeta (2005), Being Cyrus and Omkara (2006). In 2009, Khan branched out into film production with his company Illuminati Films' first film Love Aaj Kal, which became a box-office success. These accomplishments have established him as one of the leading actors of Hindi cinema. He was awarded the Padma Shri by the government of India in 2010.
He is the son of the cricket player Mansoor Ali Khan Pataudi, and actress Sharmila Tagore. Khan was married to actress Amrita Singh from 1991 to 2004, having two children together. In 2012, he married actress Kareena Kapoor on 16 October after a five-year relationship